CrossCards is a conglomoration of poker and crosswords.

MacXword, as the name suggests, is a crossword game. You open up a crossword file made from Across Lite and solve it.

Word Search is a crosswords maker for early Macs.  You can make a words list and then hit the "Make Puzzle" menu item to generate a crosswords sheet.  You can then print it on real paper.  There is no clickable words or...

Word Wonder is a nice little crossword game for early B&W Macs, but it still works in Mac OS 9, almost 20 years after its release.  It features nice 8-bit chip sound effects and a clean and simple interface.  

WordSmith is a fun crosswords game in which you click and drag the mouse in any adjacent letter to form a word.  What's fun is that you can do shapes, not just straight lines, so you could draw a "S" if the letters form a word...

X-Words Deluxe is a crossword game for Mac.